Thymosin Beta-4 is a small, endogenous peptide that is originally isolated from the Thymus gland and comprises 43 amino acids. The thymus starts to atrophy around age 15 and continues to decline until approximately 80-90% of its activity has decreased by age 35-45, this is when the chronic diseases of aging start becoming prevalent. The CDC states that approximately 80% of aged individuals are affected by at least one chronic disease due to declination of thymic related immune function.

Injury
Recovery

Boosts Immune
System

Soft Tissue
Repair

Nerve
Regeneration

Improves Heart
Health

Prevents Scar
Tissue

Wound Healing

TB4 Fragment may accelerate wound healing by promoting cell migration and tissue repair including skin and internal injuries

Cardioprotective

Animal studies suggest that TB4 Fragment may protect the heart from damage and improve cardiac function

Angiogensis

TB4 Fragment potentially stimulates blood vessel growth at the site of injury, which is crucial for wound healing and tissue repair

Anti-Fibrotic

In animal research, TB4 shows promise in inhibiting the formation of adhesions and reduces scar tissue formation by inhibiting fibrosis. This would potentially be a powerful benefit in post trauma and post-surgery to allow proper motion in muscle fiber and aid in the healing process

Immunimidulatory

Promising animal research may show that TB4 frag modulates the immune system, potentially
leading to therapeutic benefits in autoimmune diseases or conditions involving immune dysregulation

Anti-Inflammatory

It has shown promising potent anti-inflammatory properties, which may help in reducing
inflammation in various conditions like arthritis, tendonitis, digestive issues, autoimmune conditions and any other ailments driven by inflammation

Neuroprotective

There’s potential evidence to suggest that TB4 Fragment has neuroprotective and neuroregenerative effect, which could possibly be beneficial for neurological conditions

Anti-Apoptotic

TB4 Fragment has been shown in animal studies to plausibly have anti-apoptotic properties,
which could protect calls from programmed cell death in various pathological conditions

Muscle Repair

Possibly aids in muscle repair and regeneration, potentially benefiting athletes and individuals recovering from injuries

THYMOSIN BETA 4 vs THYMOSIN BETA 4 FRAGMENT (Oral Availability)

Thymosin beta 4 is a natural human protein and is made up of 43 amino acids. It is capable of binding to actin proteins and is considered to be the principal actin-sequestering protein in most cells. It therefore plays a very important role in the polymerization of actin filaments, which are important for cell structure, cell mobility, and extracellular matrix function. There is speculation, though currently no concrete evidence, to suggest that thymosin beta 4 binds to extracellular receptors in the fluids surrounding cells to mediate some of its effects.

Like many naturally occurring proteins, Thymosin Beta 4 is a very long peptide sequence and is therefore restricted to subcutaneously administration only. It is not orally bioavailable like this fragment. Because TB4 Fragment is substantially smaller than its parent molecule, it’s more readily absorbed by the GI tract and then by cells. This enhanced oral bioavailability makes TB4 Fragment (Ac-SDKP) simpler to administer than the 43 amino acid Thymosin Beta 4 and contributes to the fragment’s efficacy.

How Does Thymosin Beta-4 Work?

TB4 has been shown in animal studies to provide a range of possible beneficial effects with the potential ability to stimulate and support tissue repair, healing, and regeneration for a range of tissues and organ systems. TB4 is shown to:

  • Supports the down-regulation of inflammation and pain
  • Angiogenesis
  • Inhibits adhesion formation during the healing process
  • Stimulate cell migration and stem cell proliferation,

  • Promote tissue regeneration and repair in various organs and systems

  • Modulates the immune system
  • Increase ATP (energy) production and protect and repair mitochondria
  • Increase antioxidant and glutathione production
  • Improve IGF-1 levels
  • TB4 has significant antimicrobial functions
  • Supports the body’s ability to stay healthy during aging. (Anti-Apoptotic). • Promote tissue regeneration and repair in various organs and systems