Advanced
Immune Support
TB4-FRAG is derived from the thymus gland, offering enhanced oral bioavailability and comprehensive recovery support as your body’s natural immune function declines with age.
Highest Quality Raw Product Sourcing
Rigorous Third Party Testing
Multi-System Regenerative Benefits
TB4-FRAG offers wide-ranging therapeutic potential across multiple biological systems, from immune modulation to tissue regeneration and neuroprotection.
Injury Recovery
Accelerates wound remodeling by promoting cell migration and tissue repair, including both skin and internal injuries.
Nerve Regeneration
Demonstrates neuroprotective and neuroregenerative effects, potentially beneficial for neurological conditions.
Immune System Support
Modulates immune function to provide therapeutic benefits in autoimmune diseases and immune dysregulation conditions.
Heart Health Support
Animal studies suggest cardioprotective properties by reducing fibrosis and apoptosis (cell death) during cardiac episodes that may protect the heart from damage and improve cardiac function in the longterm.
Soft Tissue Recovery
Aids in muscle remediation and regeneration, potentially benefiting athletes and individuals recovering from injuries.
Prevents Scar Tissue
Shows promise in inhibiting adhesion formation and reducing scar tissue by inhibiting fibrosis, crucial for post-trauma recovery.
Wound Remodeling
Stimulates cellular migration and blood vessel growth through angiogenesis at injury sites, crucial for effective wound healing and tissue recovery.
Anti-Inflammatory
Demonstrates potent anti-inflammatory properties, helping reduce inflammation in arthritis, tendonitis, and autoimmune conditions.
Age-Related Immune Decline
Like most naturally occurring peptides, the endogenous production of Ac-SDKP decreases with age. Its levels are regulated by specific enzymatic pathways that become less efficient over time, leading to reduced natural concentrations. Similarly, the production of Ac-LKKTETQ also declines as the body ages, contributing to impaired healing and increased fibrosis in older individuals. Supplementation with these peptides offers the potential to counteract this age-related decline, helping to restore essential repair mechanisms and support healthier tissue regeneration.
TB4-FRAG vs Thymosin Beta-4
Understanding the key differences and advantages of TB4-FRAG
| Feature / Attribute | TB4-FRAG (Ac-SDKP & Ac-LKKTETQ) | Thymosin Beta 4 (TB4) |
| Molecular Size | Smaller peptide fragments | Full-length peptide, larger in size |
| Oral Bioavailability | Enhanced due to it’s smaller size | Poor oral bioavailability, generally requires injection |
| Key Functional Aspects | Focus on anti-inflammatory, antifibrotic, angiogenic effects, immune support | Regenerative, immune modulatory, wound healing, and cardiovascular support |
| Tissue Penetration | Better tissue penetration due to smaller size | Larger molecule, comparatively less tissue penetration |
| Potency | Potent at lower doses due to targeted fragment activity | Robust overall but less specific |
| Application Form | Oral delivery system | Subcutaneous injection |
| Aging & Natural Production | Levels decline with age; supplementation aims to restore | Also decreases with age |
Thymosin Beta-4
Original 43 amino acid protein
- Subcutaneous administration only
- Not orally bioavailable
- Larger peptide sequence (43 amino acids)
- Subcutaneous administration only
- Not orally bioavailable
- Larger peptide sequence (43 amino acids)
TB4-FRAG (Ac-SDKP)
Enhanced bioavailable fragment
- Orally bioavailable
- Enhanced GI tract absorption
- Substantially smaller peptide
- Simpler administration
- Enhanced cellular uptake
How TB4-FRAG Works
TB4-FRAG operates through multiple pathways to provide comprehensive healing and regenerative support, targeting cellular processes essential for optimal health and recovery.
Anti-inflammatory effects
via inhibition of pro-inflammatory cytokines such as IL-17 and NF-κB signaling pathways, reducing leukocyte infiltration and inflammation in tissue.
Antifibrotic activity
through suppression of TGF-β signaling and inhibition of myofibroblast differentiation (α-SMA expression), limiting fibrosis and extracellular matrix deposition in organs such as lung and heart.
Pro-angiogenic properties
promoting vascular repair and new blood vessel formation by enhancing VEGF-mediated processes that foster new blood vessel formation.
Potential preventing adverse remodeling
in cardiac fibroblasts. Potential preventing adverse remodeling in cardiac fibroblasts. Inhibition of collagen production and reduction of endoplasmic reticulum (ER) stress-associated unfolded protein responses (UPR) by down regulating CHOP/NF-κB/IL-6 pathways.
Immunomodulatory effects
Ac-SDKP reduces inflammatory cell infiltration by inhibiting pro-inflammatory cytokines and signaling pathways such as NF-κB and IL-17, thereby suppressing chronic inflammation in tissues like heart, kidney, and lung. It also modulates the renin-angiotensin system, with its production being regulated by enzymes like prolyl oligopeptidase and meprin-α, influencing immune cell behavior and inflammation. Pre-clinical studies show that AC-LKKTETQ regulates cell migration and tissue repair processes, indirectly affecting immune response and inflammation resolution.
Enhancement of wound recovery
Promotion of cell migration, particularly keratinocytes and endothelial cells, which accelerates re-epithelialization and wound closure. Activation of extracellular signal-regulated kinase (ERK) pathways, which promote cell proliferation and migration essential for repair. Modulation of TGF-β signaling to reduce fibrosis and excessive scarring, thereby supporting balanced tissue remodeling and functional recovery. Activation of extracellular signal-regulated kinase (ERK) pathways, which promote cell proliferation and migration essential for repair.
WHY CHOOSE BIOTHRIVE
- Clinician owned, Operated and Curated Product line
- Highest Quality Raw Product Sourcing
- Rigorous Third Party Testing
What Our Customers Say
We believe in the transformative potential of these powerful compound and their ability to revolutionize how we approach recovery and performance enhancement.